The entire structure of Tune Up is built on ii V I’s moving through multiple keys. So the first thing that's mandatory if you want to play this tune well, is practice ii V Is.

Working through essential lines and understanding how the chords connect is the foundation. Your goal is to be able to easily hear the resolution from ii to V to I and be able to navigate it smoothly as the key centers shift.

One of the key transitions in Tune Up is how each section moves from a major chord into its parallel minor to set up the next ii V I. This is what connects the progression as it cycles downward through different tonal centers.

Practicing ii V Is moving like this is essential if you want to be able to solo over Tune Up at tempo.

This is one of those tunes where the recordings show you how to actually deal with the changes.

Hearing how great players navigate the ii V Is, handle the key changes, and phrase over the form gives you a clear model for how the tune works in real time. Transcribing and studying even a single chorus will give you ten times more clarity than staring at a chord chart.